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SECTION I Physiologic Systems
1 An Outline of Cardiovascular Structure and Function
2 Endocrine System
3 Nervous System
4 Vision System
5 Auditory System
6 The Gastrointestinal System
7 Respiratory System
SECTION II Bioelectric Phenomena
8 Basic Electrophysiology
9 Volume Conductor Theory
10 The Electrical Conductivity of Tissues
11 Membrane Models
12 Numerical Methods for Bioelectric Field Problems
13 Principles of Electrocardiography
14 Principles of Electromyography
15 Principles of Electroencephalography
16 Biomagnetism
17 Electric Stimulation of Excitable Tissue
Section III Biomechanics
18 Mechanics of Hard Tissue
19 Mechanics of Blood Vessels
20 Joint-Articulating Surface Motion
21 Joint Lubrication
22 Musculoskeletal Soft Tissue Mechanics
23 Mechanics of Head/Neck
24 Biomechanics of Chest and Abdomen Impact
25 Analysis of Gait
26 Exercise Physiology
27 Factors Affecting Mechanical Work in Humans
28 Cardiac Biodynamics
29 Heart Valve Dynamics
30 Arterial Macrocirculatory Hemodynamics
31 Mechanics and Transport in the Microcirculation
32 Mechanics and Deformability of Hematocytes
33 The Venous System
34 Mechanics of Tissue/Lymphatic Transport
35 Cochlear Mechanics
36 Vestibular Mechanics
Section IV Biomaterials
37 Metallic Biomaterials
39 Polymeric Biomaterials
40 Composite Biomaterials
41 Biodegradable Polymeric Biomaterials: An Updated Overview
42 Biologic Biomaterials: Tissue-Derived Biomaterials (Collagen)
43 Soft Tissue Replacements
44 Hard Tissue Replacements
45 Preservation Techniques for Biomaterials
46 Hip Joint Prosthesis Fixation—Problems and Possible Solutions
Section V Biomedical Sensors
47 Physical Measurements
48 Biopotential Electrodes
49 Electrochemical Sensors
50 Optical Sensors
51 Bioanalytic Sensors
Section VI Biomedical Signal Analysis
52 Biomedical Signals: Origin and Dynamic Characteristics; Frequency-Domain Analysis
53 Digital Biomedical Signal Acquisition and Processing
54 Compression of Digital Biomedical Signals
55 Time-Frequency Signal Representations for Biomedical Signals
56 Wavelet (Time-Scale) Analysis in Biomedical Signal Processing
57 Higher-Order Spectral Analysis
58 Neural Networks in Biomedical Signal Processing
59 Complexity, Scaling, and Fractals in Biomedical Signals
60 Future Directions: Biomedical Signal Processing and Networked Multimedia Communications
Section VII Imaging
61 X-Ray
62 Computed Tomography
63 Magnetic Resonance Imaging
64 Nuclear Medicine
65 Ultrasound
66 Magnetic Resonance Microscopy
67 Positron-Emission Tomography (PET)
68 Electrical Impedance Tomography
69 Medical Applications of Virtual Reality Technology
Section VIII Medical Instruments and Devices
70 Biopotential Amplifiers
71 Noninvasive Arterial Blood Pressure and Mechanics
72 Cardiac Output Measurement
73 Bioelectric Impedance Measurements
74 Respiration
75 Clinical Laboratory: Separation and Spectral Methods
76 Clinical Laboratory: Nonspectral Methods and Automation
77 Implantable Cardiac Pacemakers
78 Implantable Stimulators for Neuromuscular Control
79 External Defibrillators
80 Implantable Defibrillators
81 Electrosurgical Devices
82 Mechanical Ventilation
83 Parenteral Infusion Devices
84 Essentials of Anesthesia Delivery
85 Biomedical Lasers
86 Noninvasive Optical Monitoring
87 Medical Instruments and Devices Used in the Home
88 Virtual Instrumentation
Section IX Biologic Effects of Nonionizing Electromagnetic Fields
89 Dielectric Properties of Tissues
90 Low-Frequency Magnetic Fields: Dosimetry, Cellular, and Animal Effects
91 Therapeutic Applications of Low-Frequency Sinusoidal and Pulsed Electric and Magnetic Fields
92 Biologic Effects of Radiofrequency and Microwave Fields: In Vivo and In Vitro Experimental Results
93 Radio Frequency Hyperthermia in Cancer Therapy
94 Electroporation of Cells and Tissues
SECTION X Transport Phenomena and Biomimetic Systems
95 Biomimetic Systems
96 Diffusional Processes and Engineering Design
97 Animal Surrogate Systems
98 Microvascular Heat Transfer
99 Interstitial Transport in the Brain: Principles for Local Drug Delivery
100 Arterial Wall Mass Transport: The Possible Role of Blood Phase Resistance in the Localization of Arterial Disease
SECTION XI Biotechnology
101 Protein Engineering
102 Monoclonal Antibodies and Their Engineered Fragments
103 Antisense Technology
104 Tools for Genome Analysis
105 Vaccine Production
106 Gene Therapy
107 Cell Engineering
108 Metabolic Engineering
SECTION XII Tissue Engineering
109 Tissue Engineering
110 Surface Immobilization of Adhesion Ligands for Investigations of Cell-Substrate Interactions
111 Biomaterials: Protein-Surface Interactions
112 Engineering Biomaterials for Tissue Engineering: The 10–100 Micron Size Scale
113 Regeneration Templates
114 Fluid Shear Stress Effects on Cellular Function
115 The Roles of Mass Transfer in Tissue Function
116 The Biology of Stem Cells
117 Cell Motility and Tissue Architecture
118 Tissue Microenvironments
119 The Importance of Stromal Cells
120 Tissue Engineering of Bone Marrow
121 Tissue Engineering of the Liver
122 Tissue Engineering in the Nervous System
123 Tissue Engineering of Skeletal Muscle
124 Tissue Engineering of Cartilage
125 Tissue Engineering of the Kidney
SECTION XIII Prostheses and Artificial Organs
126 Artificial Heart and Circulatory Assist Devices
127 Cardiac Valve Prostheses
128 Vascular Grafts
129 Artificial Lungs and Blood-Gas Exchange Devices
130 Artificial Kidney
131 Peritoneal Dialysis Equipment
132 Therapeutic Apheresis and Blood Fractionation
133 Liver Support Systems
134 Artificial Pancreas
135 Nerve Guidance Channels
136 Tracheal, Laryngeal, and Esophageal Replacement Devices
137 Artificial Blood
138 Artificial Skin and Dermal Equivalents
SECTION XIV Rehabiliation Engineering
139 Rehabilitation Engineering, Science, and Technology
140 Orthopedic Prosthetics and Orthotics in Rehabilitation
141 Wheeled Mobility: Wheelchairs and Personal Transportation
142 Externally Powered and Controlled Orthotics and Prosthetics
143 Sensory Augmentation and Substitution
144 Augmentative and Alternative Communication
145 Measurement Tools and Processes in Rehabilitation Engineering
146 Rehabilitation Engineering Technologies: Principles of Application
SECTION XV Human Performance Engineering
147 A Working Model for Human System-Task Interfaces
148 Measurement of Neuromuscular Performance Capacities
149 Measurement of Sensory-Motor Control Performance Capacities: Tracking Tasks
150 Measurement of Information-Processing Performance Capacities
151 High-Level Task Analysis: Mental Components
152 Task Analysis and Decomposition: Physical Components
153 Human-Computer Interface Design Issues
154 Applications of Human Performance Measurements to Clinical Trials to Determine Therapy Effectiveness and Safety
155 Applications of Quantitative Assessment of Human Performance in Occupational Medicine Mohamad Parnianpour
156 Human Performance Engineering: Computer-Based Design and Analysis Tools
157 Human Performance Engineering: Challenges and Prospects for the Future
SECTION XVI Physiological Modeling, Simulation, and Control
158 Modeling Strategies in Physiology
159 Compartmental Models of Physiologic Systems
160 Cardiovascular Models and Control
161 Respiratory Models and Control
162 Neural Networks for Physiological Control
163 Methods and Tools for Identification of Physiologic Systems
164 Autoregulating Windkessel Dynamics May Cause Low Frequency Oscillations
165 Control of Movements
166 The Fast Eye Movement Control System
SECTION XVII Clinical Engineering
167 Clinical Engineering: Evolution of a Discipline
168 Management and Assessment of Medical Technology
169 Risk Factors, Safety, and Management of Medical Equipment
170 Clinical Engineering Program Indicators
171 Quality of Improvement and Team Building
172 A Standards Primer for Clinical Engineers
173 Regulatory and Assessment Agencies
174 Applications of Virtual Instruments in Health Care
SECTION XVIII Medical Informatics
176 Computer-Based Patient Records
177 Computer Networks in Health Care
178 Overview of Standards Related to the Emerging Health Care Information Infrastructure
179 Non-AI Decision Making
180 Design Issues in Developing Clinical Decision Support and Monitoring Systems
SECTION XIX Artificial Intelligence
181 Artificial Intelligence in Medical Decision Making: History, Evolution, and Prospects
182 Artificial Neural Networks: Definitions, Methods, Applications
183 Clinical Decision Systems
184 Expert Systems: Methods and Tools
185 Knowledge Acquisition and Representation
186 Knowledge-Based Systems for Intelligent Patient Monitoring and Management in Critical Care Environments
187 Medical Terminology and Diagnosis Using Knowledge Bases
188 Natural Language Processing in Biomedicine
SECTION XX Ethical Issues Associated with the Use of Medical Technology
189 Professional Ethics in Biomedical Engineering
190 Beneficence, Nonmaleficence, and Technological Progress
191 Ethical Issues of Animal and Human Experimentation in the Development of Medical Devices
192 Regulation of Medical Device Innovation
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The Biomedical Engineering HandBook,
Second Edition.
Ed. Joseph D. Bronzino
Second Edition.
Ed. Joseph D. Bronzino
Table of Contents
1 An Outline of Cardiovascular Structure and Function
2 Endocrine System
3 Nervous System
4 Vision System
5 Auditory System
6 The Gastrointestinal System
7 Respiratory System
SECTION II Bioelectric Phenomena
8 Basic Electrophysiology
9 Volume Conductor Theory
10 The Electrical Conductivity of Tissues
11 Membrane Models
12 Numerical Methods for Bioelectric Field Problems
13 Principles of Electrocardiography
14 Principles of Electromyography
15 Principles of Electroencephalography
16 Biomagnetism
17 Electric Stimulation of Excitable Tissue
Section III Biomechanics
18 Mechanics of Hard Tissue
19 Mechanics of Blood Vessels
20 Joint-Articulating Surface Motion
21 Joint Lubrication
22 Musculoskeletal Soft Tissue Mechanics
23 Mechanics of Head/Neck
24 Biomechanics of Chest and Abdomen Impact
25 Analysis of Gait
26 Exercise Physiology
27 Factors Affecting Mechanical Work in Humans
28 Cardiac Biodynamics
29 Heart Valve Dynamics
30 Arterial Macrocirculatory Hemodynamics
31 Mechanics and Transport in the Microcirculation
32 Mechanics and Deformability of Hematocytes
33 The Venous System
34 Mechanics of Tissue/Lymphatic Transport
35 Cochlear Mechanics
36 Vestibular Mechanics
Section IV Biomaterials
37 Metallic Biomaterials
39 Polymeric Biomaterials
40 Composite Biomaterials
41 Biodegradable Polymeric Biomaterials: An Updated Overview
42 Biologic Biomaterials: Tissue-Derived Biomaterials (Collagen)
43 Soft Tissue Replacements
44 Hard Tissue Replacements
45 Preservation Techniques for Biomaterials
46 Hip Joint Prosthesis Fixation—Problems and Possible Solutions
Section V Biomedical Sensors
47 Physical Measurements
48 Biopotential Electrodes
49 Electrochemical Sensors
50 Optical Sensors
51 Bioanalytic Sensors
Section VI Biomedical Signal Analysis
52 Biomedical Signals: Origin and Dynamic Characteristics; Frequency-Domain Analysis
53 Digital Biomedical Signal Acquisition and Processing
54 Compression of Digital Biomedical Signals
55 Time-Frequency Signal Representations for Biomedical Signals
56 Wavelet (Time-Scale) Analysis in Biomedical Signal Processing
57 Higher-Order Spectral Analysis
58 Neural Networks in Biomedical Signal Processing
59 Complexity, Scaling, and Fractals in Biomedical Signals
60 Future Directions: Biomedical Signal Processing and Networked Multimedia Communications
Section VII Imaging
61 X-Ray
62 Computed Tomography
63 Magnetic Resonance Imaging
64 Nuclear Medicine
65 Ultrasound
66 Magnetic Resonance Microscopy
67 Positron-Emission Tomography (PET)
68 Electrical Impedance Tomography
69 Medical Applications of Virtual Reality Technology
Section VIII Medical Instruments and Devices
70 Biopotential Amplifiers
71 Noninvasive Arterial Blood Pressure and Mechanics
72 Cardiac Output Measurement
73 Bioelectric Impedance Measurements
74 Respiration
75 Clinical Laboratory: Separation and Spectral Methods
76 Clinical Laboratory: Nonspectral Methods and Automation
77 Implantable Cardiac Pacemakers
78 Implantable Stimulators for Neuromuscular Control
79 External Defibrillators
80 Implantable Defibrillators
81 Electrosurgical Devices
82 Mechanical Ventilation
83 Parenteral Infusion Devices
84 Essentials of Anesthesia Delivery
85 Biomedical Lasers
86 Noninvasive Optical Monitoring
87 Medical Instruments and Devices Used in the Home
88 Virtual Instrumentation
Section IX Biologic Effects of Nonionizing Electromagnetic Fields
89 Dielectric Properties of Tissues
90 Low-Frequency Magnetic Fields: Dosimetry, Cellular, and Animal Effects
91 Therapeutic Applications of Low-Frequency Sinusoidal and Pulsed Electric and Magnetic Fields
92 Biologic Effects of Radiofrequency and Microwave Fields: In Vivo and In Vitro Experimental Results
93 Radio Frequency Hyperthermia in Cancer Therapy
94 Electroporation of Cells and Tissues
SECTION X Transport Phenomena and Biomimetic Systems
95 Biomimetic Systems
96 Diffusional Processes and Engineering Design
97 Animal Surrogate Systems
98 Microvascular Heat Transfer
99 Interstitial Transport in the Brain: Principles for Local Drug Delivery
100 Arterial Wall Mass Transport: The Possible Role of Blood Phase Resistance in the Localization of Arterial Disease
SECTION XI Biotechnology
101 Protein Engineering
102 Monoclonal Antibodies and Their Engineered Fragments
103 Antisense Technology
104 Tools for Genome Analysis
105 Vaccine Production
106 Gene Therapy
107 Cell Engineering
108 Metabolic Engineering
SECTION XII Tissue Engineering
109 Tissue Engineering
110 Surface Immobilization of Adhesion Ligands for Investigations of Cell-Substrate Interactions
111 Biomaterials: Protein-Surface Interactions
112 Engineering Biomaterials for Tissue Engineering: The 10–100 Micron Size Scale
113 Regeneration Templates
114 Fluid Shear Stress Effects on Cellular Function
115 The Roles of Mass Transfer in Tissue Function
116 The Biology of Stem Cells
117 Cell Motility and Tissue Architecture
118 Tissue Microenvironments
119 The Importance of Stromal Cells
120 Tissue Engineering of Bone Marrow
121 Tissue Engineering of the Liver
122 Tissue Engineering in the Nervous System
123 Tissue Engineering of Skeletal Muscle
124 Tissue Engineering of Cartilage
125 Tissue Engineering of the Kidney
SECTION XIII Prostheses and Artificial Organs
126 Artificial Heart and Circulatory Assist Devices
127 Cardiac Valve Prostheses
128 Vascular Grafts
129 Artificial Lungs and Blood-Gas Exchange Devices
130 Artificial Kidney
131 Peritoneal Dialysis Equipment
132 Therapeutic Apheresis and Blood Fractionation
133 Liver Support Systems
134 Artificial Pancreas
135 Nerve Guidance Channels
136 Tracheal, Laryngeal, and Esophageal Replacement Devices
137 Artificial Blood
138 Artificial Skin and Dermal Equivalents
SECTION XIV Rehabiliation Engineering
139 Rehabilitation Engineering, Science, and Technology
140 Orthopedic Prosthetics and Orthotics in Rehabilitation
141 Wheeled Mobility: Wheelchairs and Personal Transportation
142 Externally Powered and Controlled Orthotics and Prosthetics
143 Sensory Augmentation and Substitution
144 Augmentative and Alternative Communication
145 Measurement Tools and Processes in Rehabilitation Engineering
146 Rehabilitation Engineering Technologies: Principles of Application
SECTION XV Human Performance Engineering
147 A Working Model for Human System-Task Interfaces
148 Measurement of Neuromuscular Performance Capacities
149 Measurement of Sensory-Motor Control Performance Capacities: Tracking Tasks
150 Measurement of Information-Processing Performance Capacities
151 High-Level Task Analysis: Mental Components
152 Task Analysis and Decomposition: Physical Components
153 Human-Computer Interface Design Issues
154 Applications of Human Performance Measurements to Clinical Trials to Determine Therapy Effectiveness and Safety
155 Applications of Quantitative Assessment of Human Performance in Occupational Medicine Mohamad Parnianpour
156 Human Performance Engineering: Computer-Based Design and Analysis Tools
157 Human Performance Engineering: Challenges and Prospects for the Future
SECTION XVI Physiological Modeling, Simulation, and Control
158 Modeling Strategies in Physiology
159 Compartmental Models of Physiologic Systems
160 Cardiovascular Models and Control
161 Respiratory Models and Control
162 Neural Networks for Physiological Control
163 Methods and Tools for Identification of Physiologic Systems
164 Autoregulating Windkessel Dynamics May Cause Low Frequency Oscillations
165 Control of Movements
166 The Fast Eye Movement Control System
SECTION XVII Clinical Engineering
167 Clinical Engineering: Evolution of a Discipline
168 Management and Assessment of Medical Technology
169 Risk Factors, Safety, and Management of Medical Equipment
170 Clinical Engineering Program Indicators
171 Quality of Improvement and Team Building
172 A Standards Primer for Clinical Engineers
173 Regulatory and Assessment Agencies
174 Applications of Virtual Instruments in Health Care
SECTION XVIII Medical Informatics
176 Computer-Based Patient Records
177 Computer Networks in Health Care
178 Overview of Standards Related to the Emerging Health Care Information Infrastructure
179 Non-AI Decision Making
180 Design Issues in Developing Clinical Decision Support and Monitoring Systems
SECTION XIX Artificial Intelligence
181 Artificial Intelligence in Medical Decision Making: History, Evolution, and Prospects
182 Artificial Neural Networks: Definitions, Methods, Applications
183 Clinical Decision Systems
184 Expert Systems: Methods and Tools
185 Knowledge Acquisition and Representation
186 Knowledge-Based Systems for Intelligent Patient Monitoring and Management in Critical Care Environments
187 Medical Terminology and Diagnosis Using Knowledge Bases
188 Natural Language Processing in Biomedicine
SECTION XX Ethical Issues Associated with the Use of Medical Technology
189 Professional Ethics in Biomedical Engineering
190 Beneficence, Nonmaleficence, and Technological Progress
191 Ethical Issues of Animal and Human Experimentation in the Development of Medical Devices
192 Regulation of Medical Device Innovation
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